HOME THE PTPome SEARCH ABOUT
The set of PTP genes in the human genome
The set includes all known protein tyrosine phosphatases (PTPs) in the published literature, verified PTPs or dual-specificity phosphatases in public data bases, and ORFs found by iterative BLAST searches with all the other sequences to find related genes and to assign alternatively spliced forms to the correct genes. To exclude synonyms, splice variants, and incorrectly assembled sequences, a data base with the amino sequences was created. To exclude pseudogenes, EST and other expression data bases were consulted, and the exon-intron structures and chromosomal locations of every gene was determined.
Click on picture to see domain structures of all PTPs.
A. Class I Cys-based PTPs: 101 genes
A.1. Classical PTPs: 38 genes
Transmembrane Classical PTPs: 21 genes
gene protein, synonymes
PTPRA RPTPα
PTPRB RPTPβ
PTPRC CD45, LCA
PTPRD RPTPδ
PTPRE RPTPε
PTPRF LAR
PTPRG RPTPγ
PTPRH SAP1
PTPRJ DEP1, CD148, RPTPη
PTPRK RPTPκ
PTPRM RPTPμ
PTPRN IA-2, Islet cell antigen 512
PTPRN2 PTPRP, RPTPπ, IA-2β, phogrin
PTPRO GLEPP1, PTP-U2, PTPROτ isoforms A/B/C
PTPRQ PTPS31
PTPRR PTP-SL, PCPTP,PTPBR7, PC12-PTP1
PTPRS RPTPσ
PTPRT RPTPρ
PTPRU PTPJ/PTP-U1/PTPRomicron isoforms 1/2/3
PTPRV OST-PTP
PTPRZ RPTPζ
None Receptor PTPs (NRPTPs): 17 genes
gene protein, synonymes
PTPN1 PTP1B
PTPN2 TCPTP, MPTP, PTP-S
PTPN3 PTPH1
PTPN4 PTP-MEG1, TEP
PTPN5 STEP
PTPN6 SHP1, PTP1C, SH-PTP1, HCP
PTPN7 HePTP, LCPTP
PTPN9 PTP-MEG2
PTPN11 SHP2, SH-PTP2, Syp, PTP1D, PTP2C, SH-PTP3
PTPN12 PTP-PEST, PTP-P19, PTPG1)
PTPN13 PTP-BAS, FAP-1, PTP1E, RIP, PTPL1, PTP-BL
PTPN14 PTP36, PEZ, PTPD2
PTPN18 PTP-HSCF, PTP20, BDP
PTPN20 TypPTP
PTPN21 PTPD1, PTP2E, PTP-RL10
PTPN22 LYP, PEP
PTPN23 HD-PTP, HDPTP, PTP-TD14, KIAA1471, DKFZP564F0923
A.2. Dual-Specific or VH1 like PTPs: 63 genes
Map Kinase Phosphatases (MKPs): 11 genes
gene protein, synonymes
DUSP1 MKP-1, 3CH134, PTPN10, erp, CL100/ HVH1
DUSP2 PAC-1
DUSP4 MKP-2, hVH2/TYP1
DUSP5 hVH3/B23
DUSP6 PYST1, MKP-3/rVH6
DUSP7 PYST2, B59, MKP-X
DUSP8 hVH5, M3/6, HB5
DUSP9 MKP-4, Pyst3
DUSP10 MKP-5
DUSP16 MKP-7, MKP-M
MK-STYX MK-STYX
Slingshots: 3 genes
gene protein, synonymes
SSH1 SSH1, slingshot 1
SSH2 SSH2, slingshot 2
SSH3 SSH3, slingshot 3
PRLs: 3 genes
gene protein, synonymes
PTP4A1 PRL-1,
PTP4A2 PRL-2, OV-1
PTP4A3 PRL-3
CDC14s: 4 genes
gene protein, synonymes
CDC14A CDC14A
CDC14B CDC14B
CDKN3 KAP
PTPDC PTPDC, PTP9Q22
PTENs: 5 genes
gene protein, synonymes
PTEN PTEN, MMAC1, TEP1
TPIP TPIPα, TPTE and PTEN homologous
TPTE PTEN-like, PTEN2
TNS Tensin
TENC1 C1-TEN, TENC1, KIAA1075
TNS3 tensin 3
Atypical Dual-Specific Phosphatases: 19 genes
gene protein, synonymes
DUSP3 VHR, T-DSP11
DUSP11 PIR1
DUSP12 HYVH1, GKAP, LMW-DSP4
DUSP13Aa BEDP
DUSP13Ba TMDP, TS-DSP6
DUSP14 MKP6, MKP-L
DUSP15 VHY, Q9H1R2
DUSP18 DUSP20, LMW-DSP20
DUSP19 DUSP17, SKRP1, LDP-2, TS-DSP1
DUSP21 LMW-DSP21, BJ-HCC-26 tumor antigen
DUSP22 VHX, MKPX, JSP1, LMW-DSP2, TS-DSP2, JKAP
DUSP23 MOSP, similar to RIKEN cDNA 2810004N20
DUSP24 MGC1136
DUSP25 VHZ, FLJ20442, LMW-DSP3
DUSP26 VHP, 'similar to RIKEN cDNA 0710001B24'
DUSP27b DUPD1, FMDSP, 'similar to cyclophilin',
EPM2A Laforin
RNGTT mRNA capping enzyme
STYX STYX
Myotubularins: 16 genes
gene protein, synonymes
MTM1 myotubularin
MTMR1 MTMR1
MTMR2 MTMR2
MTMR3 MTMR3, FYVE-DSP1
MTMR4 MTMR4, FYVE-DSP2
MTMR5 MTMR1, SBF1
MTMR6 MTMR6
MTMR7 MTMR7
MTMR8 MTMR8
MTMR9 MTMR9, LIP-STYX
MTMR10 MTMR10
MTMR11 MTMP11, CRA α/β
MTMR12 MTMR12, 3-PAP
MTMR13 MTMR13, SBF2, CMT4B2
MTMR14 FLJ22075, hJumpy, hEDTP
Inositol 4-phosphatases: 2 genes
gene protein, synonymes
INPP4A Inositol 4-phosphatase type I
INPP4B Inositol 4-phosphatase type II
Inositol 5-phosphatases??
B. Class II Cys-based PTPs: 1 gene
gene protein, synonymes
ACP1 LMPTP, low Mr PTP, LMWPTP, BHPTP
SSU72 Ssu72
C. Class III Cys-based PTPs: 3 genes
gene protein, synonymes
CDC25A CDC25A
CDC25B CDC25B
CDC25C CDC25C
D. Asp-based PTPs: 4 genes
gene protein, synonymes
EYA1 Eya1
EYA1 Eya2
EYA1 Eya3
EYA1 Eya4

a the human DUSP13 gene contains two DSP genes: DUSP13A (BEDP; 3 exons), two non-coding exons, followed by DUSP13B (TMDP; 3 exons). In the mouse, the two genes are designated as separate genes.

b formerly DUPD1, but does not contain an N-terminal cyclophilin domain, as originally annotated.  The mouse ortholog also lacks cyclophilin domain. Thus, the name DUPD1 is a misnomer. 
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Content: Tomas Mustelin, Website: Lutz Tautz